Primary lacrimal sac diffuse large B-cell lymphoma in a child

Deep Parikh; Rand Rodgers; Sylvia Kodsi

doi:10.1016/j.jaapos.2018.06.009

Primary lacrimal sac diffuse large B-cell lymphoma in a child

J AAPOS. 2019 Feb;23(1):53-55. doi: 10.1016/j.jaapos.2018.06.009. Epub 2018 Nov 1.

Authors

Deep Parikh¹, Rand Rodgers², Sylvia Kodsi²

Affiliations

¹ Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York. Electronic address: deep.parikh@gmail.com.
² Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, New York.

PMID: 30391376
DOI: 10.1016/j.jaapos.2018.06.009

Abstract

We report the case of a 13-year-old boy who presented with a 2-month history of left eyelid swelling, ecchymosis, and epiphora. Magnetic resonance imaging revealed a lobulated lesion in the region of the left lacrimal sac extending to the left nasolacrimal duct. Biopsy revealed diffuse large B-cell lymphoma of the lacrimal sac. Chemotherapy was initiated, consisting of rituximab, methotrexate, cytarabine, doxorubicin, cyclophosphamide, and vincristine. The lesion resolved within weeks of treatment, and the patient remained disease free at 1 year. Primary orbital lymphoma is rare in children; primary diffuse large B-cell lymphoma of the lacrimal sac in a child has not been reported previously.

Publication types

Case Reports

MeSH terms

Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Eye Neoplasms / diagnosis
Eye Neoplasms / drug therapy*
Humans
Lacrimal Apparatus Diseases / diagnosis
Lacrimal Apparatus Diseases / drug therapy*
Lymphoma, Large B-Cell, Diffuse / diagnosis
Lymphoma, Large B-Cell, Diffuse / drug therapy*
Male
Nasolacrimal Duct
Treatment Outcome