Conventional Treatment of Hypoparathyroidism

Muriel Babey; Maria-Luisa Brandi; Dolores Shoback

doi:10.1016/j.ecl.2018.07.012

Conventional Treatment of Hypoparathyroidism

Endocrinol Metab Clin North Am. 2018 Dec;47(4):889-900. doi: 10.1016/j.ecl.2018.07.012.

Authors

Muriel Babey¹, Maria-Luisa Brandi², Dolores Shoback³

Affiliations

¹ Department of Medicine, Highland Hospital, 1411 East 31st Street, Oakland, CA 94602, USA.
² Department of Surgery and Translational Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.
³ Endocrine Research Unit, Department of Medicine, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, 111N, 1700 Owens Street, 3rd Floor Room 369, San Francisco, CA 94158, USA. Electronic address: Dolores.shoback@ucsf.edu.

PMID: 30390820
DOI: 10.1016/j.ecl.2018.07.012

Abstract

Conventional therapy of hypoparathyroidism consists of oral calcium and either activated vitamin D or vitamin D supplements at varying doses. Although adjusting dosing of calcium and/or activated vitamin D or vitamin D itself, the serum calcium should be obtained weekly or monthly depending on the clinical situation. Calcium supplementation in hypoparathyroidism usually consists of calcium carbonate because it is 40% elemental calcium by weight. However, calcium citrate (21% elemental calcium) is indicated for patients with achlorhydria and proton pump inhibitor therapy. Many clinicians prefer to uptitrate the activated form of vitamin D to reduce the amount of calcium supplementation.

Keywords: Calcitriol; Hypocalcemia; Hypoparathyroidism; PTH; Serum calcium; Serum phosphate.

Publication types

Review

MeSH terms

Calcium / therapeutic use
Dietary Supplements
Humans
Hypoparathyroidism / diet therapy
Hypoparathyroidism / drug therapy*
Vitamin D / therapeutic use
Vitamins / therapeutic use

Substances

Vitamins
Vitamin D
Calcium