Pathogenesis, Genetics, and Genomics of Non-High Grade Serous Ovarian Cancers

Narthana Ilenkovan; Charlie Gourley

doi:10.1016/j.hoc.2018.07.004

Pathogenesis, Genetics, and Genomics of Non-High Grade Serous Ovarian Cancers

Hematol Oncol Clin North Am. 2018 Dec;32(6):929-942. doi: 10.1016/j.hoc.2018.07.004. Epub 2018 Oct 1.

Authors

Narthana Ilenkovan¹, Charlie Gourley²

Affiliations

¹ Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.
² Nicola Murray Centre for Ovarian Cancer Research, Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address: Charlie.gourley@ed.ac.uk.

PMID: 30390766
DOI: 10.1016/j.hoc.2018.07.004

Abstract

The 5 main non-high grade serous epithelial ovarian cancers (clear cell, low grade endometrioid, low grade serous, mucinous, and carcinosarcoma) are discrete in terms of their pathogenesis, molecular biology, and treatment sensitivity. This article reviews the current understanding of their pathogenesis and molecular biology, highlighting areas of uncertainty where future research efforts should be focused.

Keywords: Carcinosarcoma; Clear cell; Endometrioid; Genomics; Low grade serous; Mucinous; Ovarian cancer; Pathogenesis.

Publication types

Review

MeSH terms

Carcinoma, Ovarian Epithelial*
Cystadenocarcinoma, Serous* / genetics
Cystadenocarcinoma, Serous* / metabolism
Cystadenocarcinoma, Serous* / pathology
Female
Genomics / methods*
Genomics / trends
Humans
Mutation*
Neoplasm Proteins* / genetics
Neoplasm Proteins* / metabolism
Ovarian Neoplasms* / genetics
Ovarian Neoplasms* / metabolism
Ovarian Neoplasms* / pathology

Substances

Neoplasm Proteins