Risk Factors for Ovarian Carcinoma

Adrianne R Mallen; Mary K Townsend; Shelley S Tworoger

doi:10.1016/j.hoc.2018.07.002

Risk Factors for Ovarian Carcinoma

Hematol Oncol Clin North Am. 2018 Dec;32(6):891-902. doi: 10.1016/j.hoc.2018.07.002. Epub 2018 Sep 27.

Authors

Adrianne R Mallen¹, Mary K Townsend², Shelley S Tworoger³

Affiliations

¹ Department of Gynecologic Oncology, Moffitt Cancer Center/University of South Florida, 12902 Magnolia Drive MCC-GME, Tampa, FL 33612, USA.
² Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive MCC-CANCONT, Tampa, FL 33612, USA.
³ Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive MCC-CANCONT, Tampa, FL 33612, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. Electronic address: Shelley.Tworoger@moffitt.org.

PMID: 30390763
DOI: 10.1016/j.hoc.2018.07.002

Abstract

Ovarian cancer is the leading gynecologic killer of women in the United States. At diagnosis, most women present with advanced-stage disease. There are currently no effective screening strategies for average-risk women, thus understanding disease development and progression is important for developing risk-reduction strategies and identifying high-risk populations who can benefit from preventive surgery. Cancer epidemiology has greatly contributed to the understanding of this complex, heterogeneous disease by identifying various factors that may modify disease development. This article comprehensively reviews the current evidence regarding risk factors using the newest epidemiologic research for further insight into this lethal disease.

Keywords: Descriptive epidemiology; Ovarian cancer; Risk factors; Risk reduction; Tumor heterogeneity.

Publication types

Review

MeSH terms

Animals
Female
Humans
Ovarian Neoplasms / mortality*
Ovarian Neoplasms / surgery*
Risk Factors
United States / epidemiology