Two neolignans from Penthorum Chinense and their antiproliferative activities

Doudou Huang; Zhiying Dong; Lei Sun; Wansheng Chen; Lianna Sun

doi:10.1080/14786419.2018.1517261

Two neolignans from Penthorum Chinense and their antiproliferative activities

Nat Prod Res. 2020 Jun;34(11):1515-1520. doi: 10.1080/14786419.2018.1517261. Epub 2018 Nov 2.

Authors

Doudou Huang¹, Zhiying Dong¹, Lei Sun¹, Wansheng Chen², Lianna Sun¹

Affiliations

¹ Department of TCM Processing, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
² Department of Pharmacy, Changzheng Hospital Second Military Medical University, Shanghai, P.R. China.

PMID: 30388890
DOI: 10.1080/14786419.2018.1517261

Abstract

Chemical investigation of Penthorum chinense resulted in the isolation of two neolignans (1 and 2) together with two known compounds (3 and 4). The structures of compounds 1 and 2 were determined by interpretation of spectroscopic data, and absolute configurations were made based on electronic circular dichroism (ECD). All compounds were evaluated for their antiproliferative activity on hepatic stellate T6 cells (HSC-T6 cells), and 1 and 2 showed moderate activity with IC₅₀ values of 15.3 and 10.1 μM, respectively.

Keywords: ECD experiment; Penthorum Chinense; neolignans.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Circular Dichroism
Hepatic Stellate Cells / drug effects*
Humans
Inhibitory Concentration 50
Lignans / chemistry
Lignans / isolation & purification*
Lignans / pharmacology
Molecular Structure
Plant Extracts / chemistry*
Plants, Medicinal / chemistry*

Substances

Antineoplastic Agents, Phytogenic
Lignans
Plant Extracts