Targeting Long Noncoding RNA in Glioma: A Pathway Perspective

Junyang Li; Yihao Zhu; Handong Wang; Xiangjun Ji

doi:10.1016/j.omtn.2018.09.023

Targeting Long Noncoding RNA in Glioma: A Pathway Perspective

Mol Ther Nucleic Acids. 2018 Dec 7:13:431-441. doi: 10.1016/j.omtn.2018.09.023. Epub 2018 Oct 2.

Authors

Junyang Li¹, Yihao Zhu¹, Handong Wang², Xiangjun Ji¹

Affiliations

¹ Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
² Department of Neurosurgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China. Electronic address: njhdwang@hotmail.com.

Abstract

Long noncoding RNAs (lncRNAs) participate extensively in biological processes of various cancers. The majority of these transcripts are uniquely expressed in differentiated tissues or specific cancer types. lncRNAs are aberrantly expressed in gliomas and exert diverse functions. In this article, we provided an overview of how lncRNAs regulate cellular processes in glioma, enumerated the lncRNAs that may act as glioma biomarkers, and showed their potential clinical implications.

Keywords: biomarker; glioma; long noncoding RNA.

Publication types

Review