Epidermal Darwinism and Competitive Equilibrium within the Epidermis

Mingxing Lei; Cheng-Ming Chuong

doi:10.1016/j.stem.2018.10.019

Epidermal Darwinism and Competitive Equilibrium within the Epidermis

Cell Stem Cell. 2018 Nov 1;23(5):627-629. doi: 10.1016/j.stem.2018.10.019.

Authors

Mingxing Lei¹, Cheng-Ming Chuong²

Affiliations

¹ Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan; Institute of New Drug Development, College of Biopharmaceutical and Food Sciences, China Medical University, Taichung 40402, Taiwan.
² Integrative Stem Cell Center, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan; Department of Pathology, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: cmchuong@usc.edu.

Abstract

In normal homeostasis, cancer defense, or stem cell therapy, epidermal progenitors undergo constant competition to reach an equilibrium state. In this issue of Cell Stem Cell, Mesa et al. (2018) and Murai et al. (2018) show that skin epidermal progenitors maintain tissue homeostasis through competitive equilibrium under physiological self-renewal or oncogenic conditions.

Epidermal Darwinism and Competitive Equilibrium within the Epidermis

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Abstract

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