Hepatitis C virus genotypes in hemodialysis patients in Angola

J Med Virol. 2019 Mar;91(3):518-521. doi: 10.1002/jmv.25354. Epub 2018 Nov 21.

Abstract

To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidirectional sequencing of the 5'-untranslated region by the Sanger method. HCV genotype 4 was largely predominant (20 cases; 74%), followed by genotypes 1b (5 cases; 18.5%), 1a and 2 (one case each; 3.7%). These results suggest that the distribution of HCV genotypes in Angola is similar to that reported from other Central African countries.

Keywords: Africa; Angola; epidemiology; genotypes; hemodialysis; hepatitis C virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angola / epidemiology
  • Cross-Sectional Studies
  • Genotype
  • Hepacivirus
  • Hepatitis Antibodies / blood
  • Hepatitis C / complications
  • Hepatitis C / epidemiology*
  • Hepatitis C / virology*
  • Humans
  • Prevalence
  • Renal Dialysis*
  • Seroepidemiologic Studies
  • Viremia / epidemiology

Substances

  • Hepatitis Antibodies