Determination of kanamycin using a molecularly imprinted SPR sensor

Lili Zhang; Cuicui Zhu; Changbao Chen; Shuhua Zhu; Jie Zhou; Minglin Wang; Pengpeng Shang

doi:10.1016/j.foodchem.2018.05.128

Determination of kanamycin using a molecularly imprinted SPR sensor

Food Chem. 2018 Nov 15:266:170-174. doi: 10.1016/j.foodchem.2018.05.128. Epub 2018 Jun 1.

Authors

Lili Zhang¹, Cuicui Zhu¹, Changbao Chen¹, Shuhua Zhu¹, Jie Zhou¹, Minglin Wang², Pengpeng Shang³

Affiliations

¹ College of Chemistry and Materials Science, Shandong Agricultural University, Taian 271018, China.
² College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China. Electronic address: mlwang@sdau.edu.cn.
³ College of Chemistry and Materials Science, Shandong Agricultural University, Taian 271018, China. Electronic address: ppshang@sdau.edu.cn.

PMID: 30381173
DOI: 10.1016/j.foodchem.2018.05.128

Abstract

A kanamycin molecular imprinted SPR sensor was prepared with 4-vinylbenzeneboronic acid as the functional monomer, polyethylene glycol acrylate and 2,2'-azo isobutyl amidine hydrochloride as the crosslinker and the initiator, respectively. Underoptimumconditions, the responseperformance of the imprinted SPR sensor to kanamycin was evaluated. The imprinted sensor had a better imprinting effect and selectivity for kanamycin thanthe non-imprinted one. The linear range of imprinted sensor for kanamycin was from 1.0 × 10^-7 to 1.0 × 10^-5 mol/L (R² = 0.9941). Based on a signal-to-noise ratio of 3, the detection limits of kanamycin were 4.33 × 10^-8 mol/L for milk powder and 1.20 × 10^-8 mol/L for honey, with the RSD as 1.18% and 0.31%, respectively.

Keywords: Kanamycin; Molecularly imprinted polymer; Surface plasmon resonance.

MeSH terms

Kanamycin / analysis*
Limit of Detection
Surface Plasmon Resonance / instrumentation*
Surface Plasmon Resonance / methods

Substances

Kanamycin