A multi-base harmonic balance method applied to Hodgkin-Huxley model

Math Biosci Eng. 2018 Jun 1;15(3):807-825. doi: 10.3934/mbe.2018036.

Abstract

Our aim is to propose a new robust and manageable technique, called multi-base harmonic balance method, to detect and characterize the periodic solutions of a nonlinear dynamical system. Our case test is the Hodgkin-Huxley model, one of the most realistic neuronal models in literature. This system, depending on the value of the external stimuli current, exhibits periodic solutions, both stable and unstable.

Keywords: Hodgkin-Huxley model; Periodic solutions; harmonic balance method.

MeSH terms

  • Action Potentials / physiology
  • Algorithms
  • Animals
  • Humans
  • Mathematical Concepts
  • Models, Neurological*
  • Neural Conduction / physiology
  • Neurons / physiology
  • Nonlinear Dynamics
  • Synaptic Transmission / physiology