Adaptive designs in clinical trials in critically ill patients: principles, advantages and pitfalls

Intensive Care Med. 2019 May;45(5):678-682. doi: 10.1007/s00134-018-5426-z. Epub 2018 Oct 30.

C H van Werkhoven¹, S Harbarth^{2

3}, M J M Bonten^{4

5}

¹ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. c.h.vanwerkhoven@umcutrecht.nl.
² Infection Control Program and WHO Collaborating Center, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
³ Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
⁴ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
⁵ Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

No abstract available

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