Abstract
The transmission of the urogenital serovars of Chlamydia trachomatis can be significantly influenced by vaginal gels. Hydroxyethyl cellulose is a commonly used gelling agent that can be found in vaginal gels. Hydroxyethyl cellulose showed a concentration-dependent growth-enhancing effect on C. trachomatis serovars D and E, with a 26.1-fold maximal increase in vitro and a 2.57-fold increase in vivo.
Keywords:
Chlamydia trachomatis; hydroxyethyl cellulose; infectivity; vaginal gel.
Copyright © 2018 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cellulose / analogs & derivatives*
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Cellulose / pharmacology
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Chlamydia trachomatis / classification
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Chlamydia trachomatis / drug effects*
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Chlamydia trachomatis / growth & development
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Chlamydia trachomatis / pathogenicity
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Colony Count, Microbial
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Culture Media / chemistry
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Culture Media / pharmacology
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Female
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Mice
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Mice, Inbred BALB C
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Serogroup
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Vagina / drug effects*
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Vagina / microbiology
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Vaginal Creams, Foams, and Jellies / chemistry*
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Virulence / drug effects
Substances
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Culture Media
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Vaginal Creams, Foams, and Jellies
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Cellulose
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hydroxyethylcellulose