Anti-Cancerous Potential of Polyphenol-Loaded Polymeric Nanotherapeutics

Molecules. 2018 Oct 27;23(11):2787. doi: 10.3390/molecules23112787.

Abstract

Recent evidence has extensively demonstrated the anticancer potential of nutraceuticals, including plant polyphenols. Polymeric nanocarrier systems have played an important role in improving the physicochemical and pharmacological properties of polyphenols, thus ameliorating their therapeutic effectiveness. This article summarizes the benefits and shortcomings of various polymeric systems developed for the delivery of polyphenols in cancer therapy and reveals some ideas for future work.

Keywords: cancer therapeutics; cell lines; nanoparticles; polymeric carriers; polyphenols.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Drug Carriers / chemistry
  • Drug Compounding
  • Drug Delivery Systems
  • Humans
  • Nanoparticles / chemistry*
  • Nanostructures / chemistry
  • Neoplasms / drug therapy
  • Polymers / chemistry*
  • Polyphenols / chemistry*
  • Polyphenols / pharmacology*
  • Polyphenols / therapeutic use
  • Theranostic Nanomedicine*

Substances

  • Antineoplastic Agents, Phytogenic
  • Drug Carriers
  • Polymers
  • Polyphenols