INCA (Peru) Study: Impact of Non-Invasive Cardiac Magnetic Resonance Assessment in the Developing World

J Am Heart Assoc. 2018 Sep 4;7(17):e008981. doi: 10.1161/JAHA.118.008981.

Abstract

Background Advanced cardiac imaging permits optimal targeting of cardiac treatment but needs to be faster, cheaper, and easier for global delivery. We aimed to pilot rapid cardiac magnetic resonance ( CMR ) with contrast in a developing nation, embedding it within clinical care along with training and mentoring. Methods and Results A cross-sectional study of CMR delivery and clinical impact assessment performed 2016-2017 in an upper middle-income country. An International partnership (clinicians in Peru and collaborators from the United Kingdom, United States, Brazil, and Colombia) developed and tested a 15-minute CMR protocol in the United Kingdom, for cardiac volumes, function and scar, and delivered it with reporting combined with training, education and mentoring in 2 centers in the capital city, Lima, Peru, 100 patients referred by local doctors from 6 centers. Management changes related to the CMR were reviewed at 12 months. One-hundred scans were conducted in 98 patients with no complications. Final diagnoses were cardiomyopathy (hypertrophic, 26%; dilated, 22%; ischemic, 15%) and 12 other pathologies including tumors, congenital heart disease, iron overload, amyloidosis, genetic syndromes, vasculitis, thrombi, and valve disease. Scan cost was $150 USD, and the average scan duration was 18±7 minutes. Findings impacted management in 56% of patients, including previously unsuspected diagnoses in 19% and therapeutic management changes in 37%. Conclusions Advanced cardiac diagnostics, here CMR with contrast, is possible using existing infrastructure in the developing world in 18 minutes for $150, resulting in important changes in patient care.

Keywords: cardiac magnetic resonance; effectiveness; impact on patient management; outcome; rapid cardiac magnetic resonance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloidosis / diagnostic imaging
  • Amyloidosis / therapy
  • Cardiomyopathies
  • Contrast Media
  • Cross-Sectional Studies
  • Delivery of Health Care
  • Developing Countries*
  • Female
  • Health Care Costs
  • Heart Defects, Congenital / diagnostic imaging
  • Heart Defects, Congenital / therapy
  • Heart Diseases / diagnostic imaging*
  • Heart Diseases / therapy
  • Heart Neoplasms / diagnostic imaging
  • Heart Neoplasms / therapy
  • Heart Valve Diseases / diagnostic imaging
  • Heart Valve Diseases / therapy
  • Humans
  • International Cooperation
  • Iron Overload / diagnostic imaging
  • Iron Overload / therapy
  • Magnetic Resonance Imaging / economics
  • Magnetic Resonance Imaging / methods
  • Magnetic Resonance Imaging, Cine / economics
  • Magnetic Resonance Imaging, Cine / methods*
  • Male
  • Middle Aged
  • Myocarditis / diagnostic imaging
  • Myocarditis / therapy
  • Peru
  • Pilot Projects
  • Time Factors
  • Vasculitis / diagnostic imaging
  • Vasculitis / therapy
  • Young Adult

Substances

  • Contrast Media