The Unique Inhibitory IgG Receptor--FcγRIIb

Zhenzhen Xu; Lipeng Liu; Zhe Cui; Kewei Bi; Nan Zhang; Yanfen Zhang; Zhongcheng Liu

doi:10.2174/0929866525666181026162216

The Unique Inhibitory IgG Receptor--FcγRIIb

Protein Pept Lett. 2018;25(11):966-972. doi: 10.2174/0929866525666181026162216.

Authors

Zhenzhen Xu^{1

2}, Lipeng Liu^{1

2}, Zhe Cui^{1

2}, Kewei Bi^{1

2}, Nan Zhang^{1

2}, Yanfen Zhang^{2

3}, Zhongcheng Liu^{1

2}

Affiliations

¹ College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
² Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China.
³ Offices of Science and Technology, Hebei University, Baoding 071002, China.

PMID: 30370842
DOI: 10.2174/0929866525666181026162216

Abstract

Background: FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo by cross-linking with the activated receptor to intracellular transduction inhibitory signals, and it plays an important biological role in the negative regulation of innate immunity and adaptive immunity. An abnormal expression of FcγRIIb on cells would result in autoimmune diseases, infectious diseases, and so forth.

Conclusion: FcγRIIb modulates immune responses and further treats related diseases by inhibiting the activation of B lymphocytes, monocytes, mast cells, and basophils induced by activating receptors. It can be used in biotherapeutic methods such as monoclonal antibodies, chimeric recombinant proteins, bispecific antibodies, etc. Our increased understanding of FcγRIIb function also has a foundation for further research and development of FcγRIIb, which also provides potentially farreaching therapeutic implications.

Keywords: BCR; Fc receptor; FcγRIIb; ITIM; IgG receptor; biological function..

Publication types

Review

MeSH terms

Animals
Disease
Humans
Immunity*
Receptors, IgG* / chemistry
Receptors, IgG* / genetics
Receptors, IgG* / immunology
Receptors, IgG* / metabolism

Substances

Fc gamma receptor IIB
Receptors, IgG