CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo

Cell Death Dis. 2018 Oct 27;9(11):1099. doi: 10.1038/s41419-018-1146-0.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alleles
  • Animals
  • Base Pair Mismatch*
  • CRISPR-Associated Protein 9 / genetics
  • CRISPR-Associated Protein 9 / metabolism
  • CRISPR-Cas Systems*
  • DEAD-box RNA Helicases / genetics
  • DEAD-box RNA Helicases / metabolism
  • DNA End-Joining Repair
  • Embryo, Mammalian
  • Gene Editing / methods*
  • Gene Editing / standards
  • Mice
  • Mice, Transgenic
  • Mutation*
  • RNA, Guide, CRISPR-Cas Systems / genetics
  • RNA, Guide, CRISPR-Cas Systems / metabolism
  • Recombinational DNA Repair
  • Ribonuclease III / genetics
  • Ribonuclease III / metabolism

Substances

  • RNA, Guide, CRISPR-Cas Systems
  • CRISPR-Associated Protein 9
  • Dicer1 protein, mouse
  • Ribonuclease III
  • DEAD-box RNA Helicases