Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects

Szu-Yin Yu; Shih-Wei Wang; Tsong-Long Hwang; Bai-Luh Wei; Chien-Jung Su; Fang-Rong Chang; Yuan-Bin Cheng

doi:10.3390/md16110404

Components from the Leaves and Twigs of Mangrove Lumnitzera racemosa with Anti-Angiogenic and Anti-Inflammatory Effects

Mar Drugs. 2018 Oct 25;16(11):404. doi: 10.3390/md16110404.

Authors

Szu-Yin Yu¹, Shih-Wei Wang^{2

3}, Tsong-Long Hwang^{4

5

6}, Bai-Luh Wei⁷, Chien-Jung Su⁸, Fang-Rong Chang^{9

10}, Yuan-Bin Cheng^{11

12}

Affiliations

¹ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. s91412232@gmail.com.
² Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. shihwei@mmc.edu.tw.
³ Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan. shihwei@mmc.edu.tw.
⁴ Graduate Institute of Natural Products, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁵ Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁷ Department of Life Science, National Taitung University, Taitung 950, Taiwan. blwei@nttu.edu.tw.
⁸ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. scj820826@gmail.com.
⁹ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.
¹⁰ National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan. aaronfrc@kmu.edu.tw.
¹¹ Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.
¹² Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.

Abstract

One new neolignan, racelactone A (1), together with seven known compounds (2-8) were isolated from the methanolic extract of the leaves and twigs of Lumnitzera racemosa. The structure of racelactone A (1) was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds 1, 4, and 5 showed significant anti-inflammatory effects with IC₅₀ values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 μM, respectively. The plausible biosynthesis pathway of racelactone A (1) was proposed.

Keywords: Lumnitzera racemosa; anti-angiogenesis; anti-inflammation; neolignan.

MeSH terms

Angiogenesis Inhibitors / chemistry*
Angiogenesis Inhibitors / isolation & purification
Angiogenesis Inhibitors / pharmacology*
Anti-Inflammatory Agents / chemistry*
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Apoptosis / drug effects
Avicennia
Combretaceae / chemistry*
Endothelial Progenitor Cells / drug effects
Humans
Lignans / chemistry*
Lignans / isolation & purification
Lignans / pharmacology*
Magnetic Resonance Spectroscopy
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plant Leaves / chemistry

Substances

Angiogenesis Inhibitors
Anti-Inflammatory Agents
Lignans
Plant Extracts