A constitutive activation of the Wnt/β-catenin pathway is an initiating event in colon carcinogenesis. We developed colon cancer cells models that highlight the non-selectivity of previously described inhibitors of the Wnt pathway and we propose our model as a suitable screening system for inhibitors of the pathway.
Keywords: Wnt/β-catenin pathway; cell models; colorectal cancer; high-throughput screening; inhibitors.