Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific

J Clin Pathol. 2019 Mar;72(3):263-264. doi: 10.1136/jclinpath-2018-205483. Epub 2018 Oct 25.
No abstract available

Keywords: cancer genetics; colorectal cancer; pcr.

Publication types

  • Letter

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Class I Phosphatidylinositol 3-Kinases / genetics*
  • Colorectal Neoplasms / enzymology
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • Exons
  • Genetic Predisposition to Disease
  • Humans
  • Microsatellite Instability
  • Mutation*
  • Phenotype
  • Proto-Oncogene Proteins B-raf / genetics*
  • Proto-Oncogene Proteins p21(ras) / genetics*

Substances

  • Biomarkers, Tumor
  • KRAS protein, human
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins p21(ras)