Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models

Enzymes. 2018:44:61-82. doi: 10.1016/bs.enz.2018.09.002. Epub 2018 Oct 12.

Abstract

Mesoporous silica nanoparticles (MSNs) provide a promising vehicle for anticancer drug delivery. Various animal studies point to the efficacy of this nanoparticle for delivering anticancer agents (drug and siRNA) to inhibit tumor growth. These studies also showed tumor accumulation of MSN nanoparticles. While the extent of tumor accumulation differed, the study showed that it is possible to achieve significant accumulation of nanoparticles in the tumor. Biocompatibility and safety of MSN were also demonstrated by these studies.

Keywords: Biocompatibility; Biodistribution; Mouse xenograft; Tumor accumulation; Tumor growth inhibition.

MeSH terms

  • Animals
  • Drug Delivery Systems*
  • Mice
  • Models, Animal*
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Neoplasms / drug therapy*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • RNA, Small Interfering / administration & dosage
  • Silicon Dioxide / administration & dosage*
  • Silicon Dioxide / chemistry
  • Silicon Dioxide / pharmacokinetics

Substances

  • RNA, Small Interfering
  • Silicon Dioxide