Reactive Oxygen Species Responsive Naturally Occurring Phenolic-Based Polymeric Prodrug

S V Berwin Singh; Angela Guma Adam; Nirmalya Tripathy; Dongwon Lee; Gilson Khang

doi:10.1007/978-981-13-0950-2_15

Reactive Oxygen Species Responsive Naturally Occurring Phenolic-Based Polymeric Prodrug

Adv Exp Med Biol. 2018:1078:291-301. doi: 10.1007/978-981-13-0950-2_15.

Authors

S V Berwin Singh^{1

2}, Angela Guma Adam³, Nirmalya Tripathy⁴, Dongwon Lee^{5

6}, Gilson Khang^{7

8}

Affiliations

¹ Department of Physiology, Research Institute for Endocrine Sciences, Chonbuk National University Medical School, Jeonju, South Korea.
² Molecular Imaging and Therapeutic Medicine Research Center, Cyclotron Research Center, Research Institute of Clinical Medicine, Biomedical Research Institute, Chonbuk National University Medical School and Hospital, Jeonju-si, Jeollabuk-do, South Korea.
³ Moringa Connect Company, Accra, Ghana.
⁴ Department of Bioengineering, University of Washington, Seattle, WA, USA.
⁵ Department of BIN Convergence Technology, Chonbuk National University, Jeonju, Chonbuk, South Korea.
⁶ Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, Chonbuk, South Korea.
⁷ Department of BIN Convergence Technology, Chonbuk National University, Jeonju, Chonbuk, South Korea. gskhang@jbnu.ac.kr.
⁸ Department of Polymer Nano Science and Technology, Chonbuk National University, Jeonju, Chonbuk, South Korea. gskhang@jbnu.ac.kr.

PMID: 30357629
DOI: 10.1007/978-981-13-0950-2_15

Abstract

Reactive Oxygen Species (ROS) play a vital role in the biological system. Exaggerated, ROS have devastating effects on the human body leading to the pathophysiological condition including the transformation of a normal cell into a cancer phenotype. Nature has blessed us with various biomolecules that we use along with our dietary supplements. Using such therapeutic small molecules covalently incorporated into biodegradable polyoxalate polymer backbone with a responsive group forms an efficient drug delivery vehicle. This chapter "Reactive oxygen species responsive naturally occurring phenolic-based polymeric prodrug" will be focusing on redox-responsive polymers incorporated with naturally occurring phenolics and clinical application.

Keywords: Polyoxalate polymers; Prodrug; Reactive oxygen species; Redox responsive polymers.

Publication types

Review

MeSH terms

Drug Delivery Systems*
Humans
Oxidation-Reduction
Phenols*
Polymers*
Prodrugs*
Reactive Oxygen Species / metabolism*

Substances

Phenols
Polymers
Prodrugs
Reactive Oxygen Species