Genetically Determined TNF-α Secretion Influences the Development of Dermatomyositis and Systemic Lupus Erythematosus

Folia Med (Plovdiv). 2018 Jun 1;60(2):216-220. doi: 10.1515/folmed-2017-0084.

Abstract

Background: Abnormal secretion of TNF-α is known to play a role in the pathogenesis of dermatomyositis and systemic lupus erythematosus.

Materials and methods: In the present study we have analyzed the concentrations of TNF-α in the sera of 30 patients with systemic lupus erythematosus (SLE), 28 with dermatomyositis (DM) and 30 healthy controls by standard ELISA tests.

Results: We have found that -308A allele increases TNF-α secretion, while -1031C and -863A alleles decrease it. The -857C/T and 489G/A polymorphisms appeared in strong linkage disequilibrium (D'=0.93) but they did not seem to affect TNF-α secretion.

Conclusion: TNF-α polymorphisms play a significant role in its secretion and influence the development of DM and SLE.

Keywords: TNF-α levels; dermatomyositis; lupus erythematosus.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Dermatomyositis / genetics*
  • Dermatomyositis / immunology
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Linkage Disequilibrium
  • Lupus Erythematosus, Systemic / genetics*
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Tumor Necrosis Factor-alpha / genetics*
  • Tumor Necrosis Factor-alpha / immunology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • TNF protein, human
  • Tumor Necrosis Factor-alpha