Sporadic and Hereditary Breast Cancer Genetics

Radiol Technol. 2018 Sep;90(1):51M-64M.

Abstract

Genetic research provides the basis for sporadic and hereditary breast cancer diagnoses. Several mutated genes in sporadic breast cancer (eg, ERBB2 and myc) and hereditary breast cancer (eg, BRCA1 and BRCA2) influence how health care professionals assess breast cancer screenings and risks. The knowledge of these genetic mutations in the context of risk management, genetic counseling, genetic testing, and ethics might improve breast cancer treatment, prevention, and awareness.

MeSH terms

  • Breast / anatomy & histology
  • Breast Neoplasms / etiology*
  • Breast Neoplasms / therapy
  • Breast Self-Examination
  • Cell Division
  • Chromosomes, Human
  • Cortactin / genetics
  • Cyclin D1 / genetics
  • Female
  • Fibroblast Growth Factor 3 / genetics
  • Genes, BRCA1
  • Genes, BRCA2
  • Genetic Counseling
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Humans
  • Male
  • Mammography
  • Mutation
  • Proto-Oncogene Proteins c-myc / genetics
  • Receptor, ErbB-2 / genetics
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Virus Infections

Substances

  • CCND1 protein, human
  • CTTN protein, human
  • Cortactin
  • FGF3 protein, human
  • Fibroblast Growth Factor 3
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Cyclin D1
  • ERBB2 protein, human
  • Receptor, ErbB-2