Gallium-Catalyzed Scriabine Reaction

Org Lett. 2018 Nov 2;20(21):6957-6960. doi: 10.1021/acs.orglett.8b03104. Epub 2018 Oct 23.

Abstract

γ-Aryl enol acetates are easily obtained from diacetoxy alkenes and electron-rich arenes at room temperature using GaCl3 as catalyst. The products can then be converted into β-aryl aldehydes. This method represents the first broadly applicable catalytic version of the Scriabine reaction. DFT computations shed light on the mechanism of this transformation.

Publication types

  • Research Support, Non-U.S. Gov't