Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology

Ran Friedman; Syma Khalid; Camilo Aponte-Santamaría; Elena Arutyunova; Marlon Becker; Kevin J Boyd; Mikkel Christensen; João T S Coimbra; Simona Concilio; Csaba Daday; Floris J van Eerden; Pedro A Fernandes; Frauke Gräter; Davit Hakobyan; Andreas Heuer; Konstantina Karathanou; Fabian Keller; M Joanne Lemieux; Siewert J Marrink; Eric R May; Antara Mazumdar; Richard Naftalin; Mónica Pickholz; Stefano Piotto; Peter Pohl; Peter Quinn; Maria J Ramos; Birgit Schiøtt; Durba Sengupta; Lucia Sessa; Stefano Vanni; Talia Zeppelin; Valeria Zoni; Ana-Nicoleta Bondar; Carmen Domene

doi:10.1007/s00232-018-0050-y

Understanding Conformational Dynamics of Complex Lipid Mixtures Relevant to Biology

J Membr Biol. 2018 Dec;251(5-6):609-631. doi: 10.1007/s00232-018-0050-y. Epub 2018 Oct 22.

Authors

Ran Friedman¹, Syma Khalid², Camilo Aponte-Santamaría^{3

4}, Elena Arutyunova⁵, Marlon Becker⁶, Kevin J Boyd⁷, Mikkel Christensen^{8

9

10}, João T S Coimbra¹¹, Simona Concilio¹², Csaba Daday¹³, Floris J van Eerden¹⁴, Pedro A Fernandes¹¹, Frauke Gräter^{4

13}, Davit Hakobyan⁶, Andreas Heuer⁶, Konstantina Karathanou¹⁵, Fabian Keller⁶, M Joanne Lemieux⁵, Siewert J Marrink¹⁴, Eric R May⁷, Antara Mazumdar¹⁴, Richard Naftalin¹⁶, Mónica Pickholz¹⁷, Stefano Piotto¹⁸, Peter Pohl¹⁹, Peter Quinn²⁰, Maria J Ramos¹¹, Birgit Schiøtt^{8

9}, Durba Sengupta²¹, Lucia Sessa¹⁸, Stefano Vanni²², Talia Zeppelin⁸, Valeria Zoni²², Ana-Nicoleta Bondar¹⁵, Carmen Domene^{23

24}

Affiliations

¹ Department of Chemistry and Biomedical Sciences and Centre of Excellence "Biomaterials Chemistry", Linnæus University, Kalmar, Sweden. ran.friedman@lnu.se.
² University of Southampton, Southampton, SO17 1BJ, UK.
³ Max Planck Tandem Group in Computational Biophysics, University of Los Andes, Bogotá, Colombia.
⁴ Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.
⁵ Department of Biochemistry, University of Alberta, Edmonton, Canada.
⁶ IPC, University of Münster, Münster, Germany.
⁷ Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, USA.
⁸ Department of Chemistry, Aarhus University, Aarhus, Denmark.
⁹ Interdisciplinary Nanoscience center (iNANO), Aarhus University, Aarhus, Denmark.
¹⁰ Sino-Danish Center for Education and Research, Beijing, China.
¹¹ UCIBIO, REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
¹² Department of Industrial Engineering, University of Salerno, Fisciano, SA, Italy.
¹³ Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.
¹⁴ GBB Institute, University of Groningen, Groningen, The Netherlands.
¹⁵ Department of Physics, Theoretical Molecular Biophysics Group, Freie Universität Berlin, Arnimallee 14, 14195, Berlin, Germany.
¹⁶ Physiology and Vascular Biology Departments, King's College London School of Medicine, London, UK.
¹⁷ Departamento de Física, Facultad de Ciencias Exactas y Naturales, CONICET-Universidad de Buenos Aires, IFIBA, Buenos Aires, Argentina.
¹⁸ Department of Pharmacy, University of Salerno, Fisciano, SA, Italy.
¹⁹ Institute of Biophysics, Johannes Kepler University, Linz, Austria.
²⁰ Biochemistry Department, King's College London, London, UK.
²¹ Physical Chemistry Division, National Chemical Laboratory, Pune, India.
²² Department of Biology, University of Fribourg, Fribourg, Switzerland.
²³ Department of Chemistry, University of Bath, Claverton Down Bath, BA2 7AY, UK.
²⁴ Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

Abstract

This is a perspective article entitled "Frontiers in computational biophysics: understanding conformational dynamics of complex lipid mixtures relevant to biology" which is following a CECAM meeting with the same name.

Keywords: Cell membrane; Computational biophysics; Lipid–protein interactions; Molecular dynamics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Membrane / chemistry*
Cell Membrane / metabolism*
Computational Biology / methods*
Lipid Bilayers / chemistry*
Molecular Dynamics Simulation
Protein Binding
Thermodynamics

Substances

Lipid Bilayers

Grants and funding

R35 GM119762/GM/NIGMS NIH HHS/United States