Multifunctional Actions of Ninjinyoeito, a Japanese Kampo Medicine: Accumulated Scientific Evidence Based on Experiments With Cells and Animal Models, and Clinical Studies

Kanako Miyano; Miki Nonaka; Miaki Uzu; Kaori Ohshima; Yasuhito Uezono

doi:10.3389/fnut.2018.00093

Multifunctional Actions of Ninjinyoeito, a Japanese Kampo Medicine: Accumulated Scientific Evidence Based on Experiments With Cells and Animal Models, and Clinical Studies

Front Nutr. 2018 Oct 8:5:93. doi: 10.3389/fnut.2018.00093. eCollection 2018.

Authors

Kanako Miyano¹, Miki Nonaka¹, Miaki Uzu¹, Kaori Ohshima^{1

2}, Yasuhito Uezono^{1

3

4

5}

Affiliations

¹ Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan.
² Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
³ Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, Japan.
⁴ Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, Japan.
⁵ Department of Comprehensive Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Abstract

Herbal medicines are currently employed for the treatment of several types of diseases, and also employed for the improvement of Quality of Life (QOL) of patients over the world, in particular, in Asian countries. In Japan, a Japanese herbal medicine namely kampo medicine has been prescribed for the improvement of QOL of patients. Ninjinyoeito (NYT), composed of 12 herbal plants, is one of kampo medicines and used for helping recovery of diseases and improving several symptoms that suffer patients such as anemia, anorexia and fatigue. Recent scientific research approaches to kampo medicines with cells and animal models enable to prove that NYT has multiple functions for improvement of symptoms. Also, clinical studies using NYT support such actions to be widely used for the improvement of symptoms that reduce the QOL of patients.

Keywords: Ninjinyoeito; herbal ingredient; kampo medicine; mixed ingredients; scientific evidence.

Publication types

Review