Sleep after TBI: How the TBI Model Systems have advanced the field

NeuroRehabilitation. 2018;43(3):287-296. doi: 10.3233/NRE-182538.

Abstract

Background: Identification and management of comorbidities in TBI has become an increasing focus for optimizing TBI outcomes. Recent meta-analyses highlight sleep disturbance and sleep disorders following TBI (Mathias & Alvaro, 2012). Improving the recognition and treatment of sleep disorders in TBI should be a central focus of rehabilitation. The Traumatic Brain Injury Model System (TBIMS) has created an infrastructure allowing multi-center investigations into sleep dysfunction in those who have had a moderate to severe TBI and received inpatient rehabilitation.

Objective: This paper will describe the 1) infrastructure used to advance sleep dysfunction/disorders research following TBI, 2) preliminary findings from these studies, and 3) repository of data which can be accessed for secondary analyses by investigators outside of the TBIMS infrastructure.

Methods: Two internal mechanisms allow investigators at TBIMS sites to collaborate on projects of shared interest: Research Modules and Special Interest Groups (SIG).

Results: To date, five studies have resulted from the TBIMS collaborative process focusing on insomnia, circadian disruption, and sleep apnea.

Conclusions: Future directions for the SIG include continued development of available knowledge and understanding of the multidimensional factors that contribute to TBI-related sleep disturbance, optimal assessment tools, effectiveness of available treatments, and treatment compliance in this population.

Keywords: Sleep disorders; sleep dysfunction; traumatic brain injury; traumatic brain injury model systems.

Publication types

  • Review

MeSH terms

  • Adult
  • Brain Injuries, Traumatic / complications
  • Brain Injuries, Traumatic / physiopathology*
  • Brain Injuries, Traumatic / therapy
  • Circadian Rhythm / physiology
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Multicenter Studies as Topic / methods*
  • Sleep / physiology*
  • Sleep Apnea Syndromes / etiology
  • Sleep Apnea Syndromes / physiopathology
  • Sleep Apnea Syndromes / therapy
  • Sleep Initiation and Maintenance Disorders / etiology
  • Sleep Initiation and Maintenance Disorders / physiopathology
  • Sleep Initiation and Maintenance Disorders / therapy
  • Sleep Wake Disorders / etiology
  • Sleep Wake Disorders / physiopathology*
  • Sleep Wake Disorders / therapy