CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment

John M Ketcham; Lisa A Marshall; Oezcan Talay

doi:10.1021/acsmedchemlett.8b00351

CCR4 Antagonists Inhibit T_reg Trafficking into the Tumor Microenvironment

ACS Med Chem Lett. 2018 Sep 10;9(10):953-955. doi: 10.1021/acsmedchemlett.8b00351. eCollection 2018 Oct 11.

Authors

John M Ketcham¹, Lisa A Marshall¹, Oezcan Talay¹

Affiliation

¹ FLX Bio, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.

Abstract

Recruitment of naturally occurring suppressive CD4⁺, CD25⁺, and FOXP3⁺ regulatory T cells (T_reg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human T_reg express CCR4 and can be recruited to the TME through the C-C chemokines CCL17 and CCL22. We have recently developed a series of potent, orally bioavailable small molecule antagonists of CCR4 that can block recruitment of T_reg into the TME.

Publication types

Editorial