CEREBRAL BLOOD FLOW AND PREDICTORS OF WHITE MATTER LESIONS IN ADULTS WITH TETRALOGY OF FALLOT

Yaqiong Chai; Jieshen Chen; Cristina Galarza; Maayke A Sluman; Botian Xu; Chau Q Vu; Edo Richard; Barbara Mulder; Benita Tamrazi; Natasha Lepore; Henri J M M Mutsaerts; John C Wood

doi:10.1109/ISBI.2018.8363812

CEREBRAL BLOOD FLOW AND PREDICTORS OF WHITE MATTER LESIONS IN ADULTS WITH TETRALOGY OF FALLOT

Proc IEEE Int Symp Biomed Imaging. 2018 Apr:2018:1309-1312. doi: 10.1109/ISBI.2018.8363812. Epub 2018 May 24.

Authors

Yaqiong Chai^{1

2

3}, Jieshen Chen^{1

4}, Cristina Galarza^{1

5}, Maayke A Sluman⁶, Botian Xu^{1

4}, Chau Q Vu^{2

3}, Edo Richard⁷, Barbara Mulder⁶, Benita Tamrazi³, Natasha Lepore^{1

2

3}, Henri J M M Mutsaerts^{8

9}, John C Wood¹⁰

Affiliations

¹ CIBORG laboratory, Department of Radiology, Children's Hospital Los Angeles, CA, USA.
² Department of Biomedical Engineering, University of Southern California, CA, USA.
³ Department of Radiology, Children's Hospital Los Angeles, CA, USA.
⁴ Department of Electrical Engineering, University of Southern California, CA, USA.
⁵ Keck School of Medicine, University of Southern California, CA, USA.
⁶ Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
⁷ Department of Neurology, Radboud University Medical Center, Amsterdam, The Netherlands.
⁸ Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
⁹ Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.
¹⁰ Division of Cardiology, Children's Hospital Los Angeles, CA, USA.

Abstract

Long-term outcomes for Tetralogy of Fallot (TOF) have improved dramatically in recent years, but survivors are still afflicted by cerebral damage. In this paper, we characterized the prevalence and predictors of cerebral silent infarction (SCI) and their relationship to cerebral blood flow (CBF) in 46 adult TOF patients. We calculated both whole brain and regional CBF using 2D arterial spin labeling (ASL) images, and investigated the spatial overlap between voxel-wise CBF values and white matter hyperintensities (WMHs) identified from T2-FLAIR images. SCIs were found in 83% of subjects and were predicted by the year of the patient's first cardiac surgery and patient's age at scanning (combined r² 0.44). CBF was not different in brain regions prone to stroke compared with healthy white matter.

Keywords: Tetralogy of Fallot; arterial spin labeling; cerebral blood flow; deep white matter lesion.

Grants and funding

U01 HL117718/HL/NHLBI NIH HHS/United States