First whole genome sequencing of Russian isolate of Capnocytophaga canimorsus, opportunistic pathogen causing lethal sepsis

Andrey A Shelenkov; Lyudmila S Karan; Yulia V Mihaylova; Yuri G Yanushevich; German A Shipulin; Dmitriy A Shagin

doi:10.1016/j.micpath.2018.10.020

First whole genome sequencing of Russian isolate of Capnocytophaga canimorsus, opportunistic pathogen causing lethal sepsis

Microb Pathog. 2018 Dec:125:493-496. doi: 10.1016/j.micpath.2018.10.020. Epub 2018 Oct 18.

Authors

Andrey A Shelenkov¹, Lyudmila S Karan¹, Yulia V Mihaylova¹, Yuri G Yanushevich¹, German A Shipulin¹, Dmitriy A Shagin²

Affiliations

¹ Central Research Institute of Epidemiology, Novogireevskaya str. 3a, Moscow, 111123, Russia.
² Central Research Institute of Epidemiology, Novogireevskaya str. 3a, Moscow, 111123, Russia. Electronic address: shagin@cmd.su.

PMID: 30342910
DOI: 10.1016/j.micpath.2018.10.020

Abstract

Capnocytophaga canimorsus is a part of healthy oral flora of dogs and cats. However, when it is transmitted to human subjects via animal bites or scratches, it can cause severe complications like endocarditis or even lethal septic shock, especially in immunocompromised persons. In this study, we performed the first whole-genome sequencing on Illumina HiSeq platform of Russian isolate of C. canimorsus that have caused lethal sepsis in 51-old male from Moscow. We believe that the availability of genomic sequence and annotation for the given strain could be useful for future epidemiological surveillance studies in Russia and other countries.

Keywords: Capnocytophaga canimorsus; Sepsis; Whole genome sequencing.

MeSH terms

Capnocytophaga / genetics*
Capnocytophaga / isolation & purification
Gram-Negative Bacterial Infections / microbiology*
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Molecular Sequence Annotation
Moscow
Sepsis / microbiology*
Sequence Analysis, DNA
Whole Genome Sequencing*