Genomic analysis of enterovirus D68, including one strain isolated from a child with Wilson's disease in Taiwan

J Formos Med Assoc. 2019 Feb;118(2):641-646. doi: 10.1016/j.jfma.2018.09.021. Epub 2018 Oct 19.

Abstract

North America experienced life-threatening outbreaks of enterovirus D68 (EV-D68) in 2014. We retrospectively detected EV-D68 from a child with Wilson's disease in 2008 in Taiwan. After comparing this EV-D68/Taiwan/2008 strain with EV-D68 genomes obtained from the public domain, it was classified as genome type 1-B; it is phylogenetically related to the predominant EV-D68 viruses that circulated in 2009 in Vietnam. It is necessary to strengthen EV-D68 detection globally, including in children with acute liver failure. Moreover, harmonization of genomic analysis of EV-D68 is desirable to understand global evolution of EV-D68.

Keywords: Enterovirus D68; Genome study; Molecular epidemiology; Next-generation sequencing.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child, Preschool
  • Disease Outbreaks
  • Enterovirus D, Human / genetics*
  • Enterovirus D, Human / isolation & purification*
  • Enterovirus Infections / epidemiology
  • Enterovirus Infections / virology*
  • Female
  • Genome, Viral
  • Global Health
  • Hepatolenticular Degeneration / epidemiology
  • Hepatolenticular Degeneration / virology*
  • Humans
  • Phylogeny
  • Retrospective Studies
  • Sequence Analysis, DNA