Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

Johanna P Laakkonen; Johanna Lähteenvuo; Suvi Jauhiainen; Tommi Heikura; Seppo Ylä-Herttuala

doi:10.1016/j.vph.2018.10.005

Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta

Vascul Pharmacol. 2019 Jan:112:91-101. doi: 10.1016/j.vph.2018.10.005. Epub 2018 Oct 17.

Authors

Johanna P Laakkonen¹, Johanna Lähteenvuo², Suvi Jauhiainen², Tommi Heikura², Seppo Ylä-Herttuala³

Affiliations

¹ A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address: johanna.p.laakkonen@uef.fi.
² A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
³ A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Science Service Center, Kuopio University Hospital, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland.

PMID: 30342234
DOI: 10.1016/j.vph.2018.10.005

Abstract

Vascular endothelial growth factors regulate vascular and lymphatic growth. Dysregulation of VEGF signaling is connected to many pathological states, including hemangiomas, arteriovenous malformations and placental abnormalities. In heart, VEGF gene transfer induces myocardial angiogenesis. Besides vascular and lymphatic endothelial cells, VEGFs affect multiple other cell types. Understanding VEGF biology and its paracrine signaling properties will offer new targets for novel treatments of several diseases.

Keywords: Angiogenesis; Arteriovenous malformation; Heart; Hemangioma; Lymphangiogenesis; Lymphatic vessel; Placenta; VEGF; VEGF receptor; Vascular endothelial growth factor; Vascular tumor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arteriovenous Malformations / genetics
Arteriovenous Malformations / metabolism*
Arteriovenous Malformations / pathology
Endothelial Cells / metabolism*
Endothelial Cells / pathology
Female
Heart Diseases / metabolism*
Heart Diseases / pathology
Hemangioma / genetics
Hemangioma / metabolism*
Hemangioma / pathology
Humans
Lymphangiogenesis
Myocardium / metabolism*
Myocardium / pathology
Neovascularization, Pathologic
Neovascularization, Physiologic
Paracrine Communication
Placenta / metabolism*
Placenta / pathology
Pregnancy
Signal Transduction
Vascular Endothelial Growth Factor A / genetics
Vascular Endothelial Growth Factor A / metabolism*

Substances

Vascular Endothelial Growth Factor A