19F MRI in orthotopic cancer model via intratracheal administration of ανβ3-targeted perfluorocarbon nanoparticles

Xiuan Xu; Ruixin Zhang; Fang Liu; Jiaqi Ping; Xiaofei Wen; Hongbin Wang; Kai Wang; Xilin Sun; Hongyan Zou; Baozhong Shen; Lina Wu

doi:10.2217/nnm-2018-0051

¹⁹F MRI in orthotopic cancer model via intratracheal administration of α_νβ₃-targeted perfluorocarbon nanoparticles

Nanomedicine (Lond). 2018 Oct;13(20):2551-2562. doi: 10.2217/nnm-2018-0051. Epub 2018 Oct 19.

Authors

Xiuan Xu^{1

2

3}, Ruixin Zhang¹, Fang Liu³, Jiaqi Ping^{1

2}, Xiaofei Wen^{1

2}, Hongbin Wang¹, Kai Wang^{1

2}, Xilin Sun^{1

2}, Hongyan Zou^{1

2}, Baozhong Shen^{1

2}, Lina Wu^{1

2}

Affiliations

¹ Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, PR China.
² TOF-PET/CT/MR center, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China.
³ Department of Medical Imaging, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, PR China.

PMID: 30338723
DOI: 10.2217/nnm-2018-0051

Abstract

Aim: To demonstrate the feasibility of intratracheal administration in orthotopic lung cancer model with ¹⁹F MRI.

Materials & methods: α_vβ₃-integrin targeting ability of the perfluorocarbon (PFC) nanoparticles was tested. Orthotopic lung cancer model was established in rabbits under computed tomography guidance. α_vβ₃-targeted PFC nanoparticles were administrated intratracheally or intravenously, and ¹⁹F MRI was performed before and up to 24 h after administration.

Results: The targeted PFC nanoparticles could bind with α_vβ₃-integrin. PFC concentrations in the tumors of intratracheal group after administration were significantly higher than intravenous group.

Conclusion: Intratracheal administration of PFC nanoparticles was shown to be feasible and efficacious. ¹⁹F MRI with α_vβ₃-targeted PFC nanoparticles provided quantitative assessment of nanoparticles distribution and tumor angiogenesis.

Keywords: 19F MR; intratracheal administration; orthotopic tumor; perfluorocarbon nanoparticles; αvβ3-integrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media
Fluorine-19 Magnetic Resonance Imaging
Humans
Integrin alphaVbeta3 / antagonists & inhibitors
Integrin alphaVbeta3 / genetics*
Lung Neoplasms / diagnostic imaging
Lung Neoplasms / drug therapy*
Lung Neoplasms / genetics
Molecular Targeted Therapy*
Neovascularization, Pathologic / diagnostic imaging
Neovascularization, Pathologic / drug therapy*
Neovascularization, Pathologic / pathology
Orthotic Devices
Rabbits

Substances

Contrast Media
Integrin alphaVbeta3