Brain-Gut Axis: Clinical Implications

Julie Khlevner; Yeji Park; Kara Gross Margolis

doi:10.1016/j.gtc.2018.07.002

Brain-Gut Axis: Clinical Implications

Gastroenterol Clin North Am. 2018 Dec;47(4):727-739. doi: 10.1016/j.gtc.2018.07.002. Epub 2018 Sep 28.

Authors

Julie Khlevner¹, Yeji Park¹, Kara Gross Margolis²

Affiliations

¹ Department of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA.
² Department of Pediatrics, Columbia University College of Physicians and Surgeons, 630 West 168th Street, PH 17, New York, NY 10032, USA. Electronic address: kjg2133@cumc.columbia.edu.

Abstract

This article provides an overarching view of what is currently known about the physiology of the brain-gut axis in both health and disease and how these concepts apply to irritable bowel syndrome, the most common functional gastrointestinal disorder in pediatrics.

Keywords: Brain–gut axis; Brain–gut–microbiome axis; Enteric nervous system; Irritable bowel syndrome; Serotonin.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Brain / physiopathology*
Gastrointestinal Microbiome / physiology*
Gastrointestinal Tract / pathology*
Gastrointestinal Tract / physiopathology*
Humans
Irritable Bowel Syndrome / etiology*

Abstract

Publication types

MeSH terms

Grants and funding