Alzheimer Disease

Clin Geriatr Med. 2018 Nov;34(4):591-601. doi: 10.1016/j.cger.2018.06.006. Epub 2018 Aug 21.

Abstract

Alzheimer disease is due to increased amyloid-β coupled with low progranulin. Several brain imaging techniques are helpful in the diagnosis. Drugs available for treating Alzheimer disease have limited clinical utility. Cognitive stimulation therapy is an effective therapy for persons with moderate Alzheimer disease.

Keywords: Amyloid-β; Biomarkers; Cognitive stimulation therapy; Olive oil; Progranulin; SAMP8.

Publication types

  • Review

MeSH terms

  • Aged
  • Alzheimer Disease* / diagnosis
  • Alzheimer Disease* / genetics
  • Alzheimer Disease* / metabolism
  • Alzheimer Disease* / therapy
  • Amyloid beta-Peptides* / genetics
  • Amyloid beta-Peptides* / metabolism
  • Brain / diagnostic imaging*
  • Cognitive Behavioral Therapy / methods
  • Disease Management
  • Genetic Predisposition to Disease
  • Humans
  • Neuropsychological Tests
  • Progranulins* / genetics
  • Progranulins* / metabolism

Substances

  • Amyloid beta-Peptides
  • Progranulins