Further new eunicellin-based diterpenoids from the Guangxi Weizhou soft coral Cladiella krempfi

Abstract

Three new polyoxygenated diterpenes (1, 3 and 4) of eunicellin-type, namely, 8-n-butyryl-litophynol A, 6-keto-litophynol B and 6-epi-litophynol B, respectively, together with two related known ones (2 and 5), were isolated from the soft coral Cladiella krempfi collected off the Weizhou island, Guangxi Zhuang Autonomous Region, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical correlation. In bioassay, all the new compounds displayed moderate anti-inflammatory effects.