Mortality-associated immunological abnormalities in trichothiodystrophy: correlation of reduced levels of immunoglobulin and neutrophils with poor patient survival

Br J Haematol. 2019 May;185(4):752-754. doi: 10.1111/bjh.15598. Epub 2018 Oct 18.

Authors

Grant Randall^{1

2}, Kenneth H Kraemer¹, Jennifer Pugh¹, Deborah Tamura¹, John J DiGiovanna¹, Sikandar G Khan¹, Karolyn A Oetjen³

Affiliations

¹ Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
² Medical Research Scholars Program, NIH, Bethesda, MD, USA.
³ Hematology Branch, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA.

No abstract available

Keywords: DNA repair disorders; hypogammaglobulinaemia; neutropenia; paediatric genetics; reduced survival.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Agammaglobulinemia / immunology
Agammaglobulinemia / mortality*
Child
Child, Preschool
Female
Humans
Immunoglobulins / deficiency
Male
Neutropenia / immunology
Neutropenia / mortality*
Neutropenia / pathology
Neutrophils / immunology
Retrospective Studies
Survival Analysis
Trichothiodystrophy Syndromes / immunology
Trichothiodystrophy Syndromes / mortality*
Trichothiodystrophy Syndromes / pathology
Young Adult

Substances

Immunoglobulins

Grants and funding