Tagatose as a Potential Nutraceutical: Production, Properties, Biological Roles, and Applications

J Food Sci. 2018 Nov;83(11):2699-2709. doi: 10.1111/1750-3841.14358. Epub 2018 Oct 18.

Abstract

Nutraceuticals are gaining importance owing to their potential applications in numerous sectors including food and feed industries. Among the emerging nutraceuticals, d-tagatose occupies a significant niche because of its low calorific value, antidiabetic property and growth promoting effects on beneficial gut bacteria. As d-tagatose is present in minute quantities in naturally occurring food substances, it is produced mainly by chemical or biological means. Recently, attempts were made for bio-production of d-tagatose using l-arabinose isomerase enzyme to overcome the challenges of chemical process of production. Applications of d-tagatose for maintaining health and wellbeing are increasing due to growing consumer awareness and apprehension against modern therapeutic agents. This review outlines the current status on d-tagatose, particularly its production, properties, biological role, applications, and the future perspectives.

Keywords: antidiabetic; d-tagatose; l-arabinose isomerase; nutraceutical.

Publication types

  • Review

MeSH terms

  • Aging / drug effects*
  • Aldose-Ketose Isomerases / metabolism
  • Anti-Obesity Agents / chemistry
  • Anti-Obesity Agents / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Bacillus subtilis
  • Corynebacterium glutamicum
  • Dietary Supplements*
  • Gastrointestinal Microbiome / drug effects
  • Hexoses / biosynthesis
  • Hexoses / chemistry*
  • Hexoses / pharmacology
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology
  • Iron Chelating Agents / chemistry*
  • Iron Chelating Agents / pharmacology
  • Lactococcus lactis
  • Prebiotics

Substances

  • Anti-Obesity Agents
  • Antioxidants
  • Hexoses
  • Hypoglycemic Agents
  • Iron Chelating Agents
  • Prebiotics
  • Aldose-Ketose Isomerases
  • L-arabinose isomerase
  • tagatose