Maternal Measles Antibodies and Their Influence on All-cause Mortality Following Measles Vaccination: An Alternative to Measure Very Low Maternal Antibody Levels

Clin Infect Dis. 2019 May 2;68(10):1758-1760. doi: 10.1093/cid/ciy900.

Abstract

It was previously shown by hemagglutination inhibition that measles vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/mL) that correlates with lower all-cause mortality (P = .02).

Keywords: HAI; all-cause mortality; maternal measles antibodies; multiplex immunoassay.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Antibodies, Viral / blood*
  • Female
  • Hemagglutination Inhibition Tests
  • Humans
  • Immunity, Maternally-Acquired*
  • Immunoassay / methods*
  • Infant
  • Measles / immunology*
  • Measles / mortality*
  • Measles Vaccine / immunology*
  • Measles virus
  • Mortality
  • Vaccination

Substances

  • Antibodies, Viral
  • Measles Vaccine