Abstract
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex, Stenotrophomonas maltophilia, Pseudomonas aeruginosa, and Enterobacteriaceae strains was determined by microdilution in iron-depleted Mueller-Hinton broth. The MIC90s against A. baumannii, S. maltophilia, and P. aeruginosa were 1, 0.25, and 0.5 mg/liter, respectively. Against Enterobacteriaceae, the MIC90 was 1 mg/liter for the group harboring OXA-48-like, 2 mg/liter for the group harboring KPC-3, and 8 mg/liter for the group harboring TEM/SHV ESBL, NDM, and KPC-2.
Keywords:
Enterobacteriaceae; Gram-negative bacteria; S-649266; cefiderocol; cephalosporin; siderophore.
Copyright © 2018 American Society for Microbiology.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / growth & development
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Anti-Bacterial Agents / pharmacology*
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Cefiderocol
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Cephalosporins / pharmacology*
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Culture Media
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Enterobacteriaceae / drug effects*
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics
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Enterobacteriaceae / growth & development
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Gene Expression
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Gram-Negative Bacterial Infections / drug therapy
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Gram-Negative Bacterial Infections / microbiology
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Humans
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / enzymology
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Pseudomonas aeruginosa / genetics
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Pseudomonas aeruginosa / growth & development
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Siderophores / pharmacology
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Stenotrophomonas maltophilia / drug effects*
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Stenotrophomonas maltophilia / enzymology
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Stenotrophomonas maltophilia / genetics
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Stenotrophomonas maltophilia / growth & development
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beta-Lactam Resistance / drug effects
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Culture Media
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Siderophores
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beta-Lactamases