Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Jihwan Son; Gawon Yi; Jihye Yoo; Changhee Park; Heebeom Koo; Hak Soo Choi

doi:10.1016/j.addr.2018.10.002

Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Adv Drug Deliv Rev. 2019 Jan 1:138:133-147. doi: 10.1016/j.addr.2018.10.002. Epub 2018 Oct 12.

Authors

Jihwan Son¹, Gawon Yi¹, Jihye Yoo¹, Changhee Park¹, Heebeom Koo², Hak Soo Choi³

Affiliations

¹ Department of Medical Lifescience, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.
² Department of Medical Lifescience, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address: hbkoo@catholic.ac.kr.
³ Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: hchoi12@mgh.harvard.edu.

Abstract

Nanoparticles (NPs) play a key role in nanomedicine in multimodal imaging, drug delivery and targeted therapy of human diseases. Consequently, due to the attractive properties of NPs including high stability, high payload, multifunctionality, design flexibility, and efficient delivery to target tissues, nanomedicine employs various types of NPs to enhance targeting and treatment efficacy. In this review, we primarily focus on light-responsive materials, such as fluorophores, photosensitizers, semiconducting polymers, carbon structures, gold particles, quantum dots, and upconversion crystals, for their biomedical applications. Armed with these nanomaterials, NPs represent a growing potential in biophotonic imaging (luminescence, photoacoustic, surface enhanced Raman scattering, and optical coherence tomography) as well as targeted therapy (photodynamic therapy, photothermal therapy, and light-responsive drug release).

Keywords: Light-responsiveness; Nanomedicine; Optical imaging; Targeted therapy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Diagnostic Imaging
Drug Delivery Systems*
Humans
Light*
Nanostructures / administration & dosage
Nanostructures / radiation effects*
Theranostic Nanomedicine

Grants and funding

R01 EB022230/EB/NIBIB NIH HHS/United States