Circulating microRNA plasma profile in MuSK+ myasthenia gravis

J Neuroimmunol. 2018 Dec 15:325:87-91. doi: 10.1016/j.jneuroim.2018.10.003. Epub 2018 Oct 6.

Abstract

Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.

Keywords: Biomarker; MuSK; Muscle-specific tyrosine kinase; Myasthenia gravis; microRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Circulating MicroRNA / blood*
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis / blood*
  • Myasthenia Gravis / diagnosis*
  • Receptor Protein-Tyrosine Kinases / blood*
  • Receptors, Cholinergic / blood*

Substances

  • Autoantibodies
  • Circulating MicroRNA
  • Receptors, Cholinergic
  • MUSK protein, human
  • Receptor Protein-Tyrosine Kinases