Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

Michael Martinez; Mari Spitali; Edith L Norrant; Daniel G Bracewell

doi:10.1016/j.tibtech.2018.09.001

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

Trends Biotechnol. 2019 Mar;37(3):237-241. doi: 10.1016/j.tibtech.2018.09.001. Epub 2018 Oct 10.

Authors

Michael Martinez¹, Mari Spitali², Edith L Norrant³, Daniel G Bracewell⁴

Affiliations

¹ Department of Biochemical Engineering, University College London, London WC1E 6BT, UK.
² UCB Pharma, Slough, Berkshire, SL1 4BG, UK.
³ UCB Pharma, Braine-l'Alleud, Brussels, Belgium.
⁴ Department of Biochemical Engineering, University College London, London WC1E 6BT, UK. Electronic address: d.bracewell@ucl.ac.uk.

PMID: 30316558
DOI: 10.1016/j.tibtech.2018.09.001

Abstract

Advances in precipitation have demonstrated the capability of purifying therapeutic proteins such as antibodies from biological sources in a scalable and cost-effective manner. We discuss the latest developments in the unit operation for downstream processing applications and provide a perspective on exploring precipitation for bioprocess intensification.

Keywords: bioprocessing; continuous; precipitation; process intensification.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products / isolation & purification*
Biotechnology / methods*
Chemical Precipitation*
Technology, Pharmaceutical / methods*

Substances

Biological Products