Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

Hua-Tsen Hsiao; Jun-Jun Lee; Hsiu-Hui Chen; Ming-Kung Wu; Chi-Wei Huang; Ya-Ting Chang; Chia-Yi Lien; Jing-Jy Wang; Hsin-I Chang; Chiung-Chih Chang

doi:10.1016/j.clnu.2018.09.017

Adequacy of nutrition and body weight in patients with early stage dementia: The cognition and aging study

Clin Nutr. 2019 Oct;38(5):2187-2194. doi: 10.1016/j.clnu.2018.09.017. Epub 2018 Sep 22.

Authors

Affiliations

¹ Department of Nursing, National Tainan Junior College of Nursing, Taiwan.
² Department of Neurology and Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
³ Department of Physical Education, National Kaohsiung University of Science and Technology, Taiwan.
⁴ Department of Psychiatry, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
⁵ Department of Nursing, College of Medicine, National Cheng Kung University, Taiwan.
⁶ Department of Neurology and Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; Institute of Human Resource Management, National Sun Yat-Sen University, Taiwan.
⁷ Department of Neurology and Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: neur099@adm.cgmh.org.tw.

PMID: 30316533
DOI: 10.1016/j.clnu.2018.09.017

Abstract

Background & aims: Recent evidence highlights the effects of obesity, diabetes and hypertension in the development of Alzheimer's disease. Involuntary body weight changes in patients with different stages of dementia can be related to clinical factors of the patient per se or support from their caregivers. Understanding the interactions among factors is important to establish a monitoring paradigm to guide treatment strategies.

Methods: A total of 345 patients with very mild (n = 224) and mild stage (n = 121) dementia were enrolled from a multi-disciplinary dementia clinic. Clinical data (comorbidities, Mini-Mental State Examination [MMSE] scores, neuropsychiatric inventory [NPI] scores, eating behavior questionnaire), nutritional state (Mini-Nutritional Assessment [MNA] or MNA short form [MNA-SF]) and body mass index (BMI) were recorded. Nutritional state and BMI served as the two major outcome measures, and factors for analysis included diagnosis, dementia severity and clinical data.

Results: There was a significant correlation between MNA-SF and MNA (r = .898, p < 0.01), but a 24% mismatch in case dislocation was found using the at-risk or malnutrition criteria. Factors related to obesity included male sex, higher MNA-SF and MNA scores, diabetes mellitus and hypertension, while acceptable discrimination for obesity (BMI≧23 kg/m²) was obtained with a MNA-SF score of 12/13 or MNA score of 21/22. NPI was the only independent factor related to both MNA-SF (β = -.06, P < 0.001) and MNA (β = -.1, P < 0.001). A BMI of 22-23 kg/m² was adequate in this group of patients with early stage dementia from nutritional and comorbidity perspectives. After controlling for BMI, the patients with advanced dementia had higher swallowing problem and appetite change scores.

Conclusions: In these patients with early stage dementia, a higher BMI indicated adequate nutritional status and higher MMSE, but also higher rates of comorbidities, diabetes mellitus and hypertension.

Keywords: Body mass index; Dementia; Eating behavior; Involuntary weight loss; Nutritional status.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Body Mass Index
Body Weight / physiology*
Dementia* / epidemiology
Dementia* / physiopathology
Feeding Behavior
Female
Humans
Male
Nutritional Status / physiology*
Risk Factors
Taiwan
Weight Loss