Advances in mechanisms of allergic disease in 2017

Abstract

This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, T_H2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (T_H2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. The plasticity of lymphocyte effector cell responses is another area in which major progress has been achieved. Accumulating evidence will influence both our understanding of allergic disease and our efforts for allergy prevention and treatment.

Keywords: Allergy; adaptive; asthma; barrier function; eosinophil; food allergy; immunology; inflammation; innate; mast cell.