Revisiting Trypanosome Mitochondrial Genome Mysteries: Broader and Deeper

Trends Parasitol. 2019 Feb;35(2):102-104. doi: 10.1016/j.pt.2018.09.006. Epub 2018 Oct 9.

Abstract

What do the products of a genome do, and when and why are they needed? For the protein products of the trypanosomatid parasites' mitochondrial genomes, the total expressed protein repertoire and the identities of the more difficult-to-characterize products have been challenging to acquire. Comparative genomics and new technologies may resolve that.

Keywords: NADH dehydrogenase; RNA editing; electron transport chain; kinetoplastid; maxicircle; mitochondrial ribosome.

Publication types

  • Review

MeSH terms

  • Genome, Mitochondrial / genetics*
  • Genome, Protozoan / genetics*
  • Protozoan Proteins / genetics
  • Trypanosoma / genetics*

Substances

  • Protozoan Proteins