Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials

Benjamin J Stenson; Mark Donoghoe; Peter Brocklehurst; Peter G Davis; Edmund Juszczak; Ian C Marschner; John Simes; William O Tarnow-Mordi

doi:10.1016/j.jpeds.2018.08.033

Pulse Oximeter Saturation Targeting and Oximeter Changes in the Benefits of Oxygen Saturation Targeting (BOOST)-II Australia and BOOST-II UK Oxygen Trials

J Pediatr. 2019 Jan:204:301-304.e2. doi: 10.1016/j.jpeds.2018.08.033. Epub 2018 Oct 9.

Authors

Benjamin J Stenson¹, Mark Donoghoe², Peter Brocklehurst³, Peter G Davis⁴, Edmund Juszczak⁵, Ian C Marschner⁶, John Simes², William O Tarnow-Mordi²

Affiliations

¹ Neonatal Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. Electronic address: ben.stenson@luht.scot.nhs.uk.
² NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia.
³ Birmingham Clinical Trials Unit, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
⁴ The Royal Women's Hospital, Department of Obstetrics and Gynecology, The University of Melbourne; Murdoch Children's Research Institute Melbourne, Melbourne, Australia.
⁵ National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
⁶ NHMRC Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia; Department of Statistics, Macquarie University, Sydney, NSW, Australia.

PMID: 30314661
DOI: 10.1016/j.jpeds.2018.08.033

Abstract

Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P < .001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.

Keywords: blindness/epidemiology; blindness/etiology; cerebral palsy/epidemiology; enterocolitis, necrotizing/epidemiology; enterocolitis, necrotizing/etiology; humans; incidence; infant; infant mortality; infant, extremely premature; infant, newborn; oximetry; oxygen/administration & dosage; oxygen/adverse effects; oxygen/blood; trial.

Publication types

Meta-Analysis

MeSH terms

Australia
Calibration
Humans
Infant
Infant Mortality*
Infant, Newborn
Oximetry / instrumentation
Oximetry / methods*
Oxygen / blood*
United Kingdom

Substances

Oxygen

Grants and funding

G0400415/MRC_/Medical Research Council/United Kingdom