Magnetic Interaction of Multifunctional Core-Shell Nanoparticles for Highly Effective Theranostics

Ming-Da Yang; Chien-Hsin Ho; Sergiu Ruta; Roy Chantrell; Kathryn Krycka; Ondrej Hovorka; Fu-Rong Chen; Ping-Shan Lai; Chih-Huang Lai

doi:10.1002/adma.201802444

Magnetic Interaction of Multifunctional Core-Shell Nanoparticles for Highly Effective Theranostics

Adv Mater. 2018 Dec;30(50):e1802444. doi: 10.1002/adma.201802444. Epub 2018 Oct 11.

Authors

Ming-Da Yang¹, Chien-Hsin Ho¹, Sergiu Ruta², Roy Chantrell², Kathryn Krycka³, Ondrej Hovorka⁴, Fu-Rong Chen⁵, Ping-Shan Lai⁶, Chih-Huang Lai¹

Affiliations

¹ Department of Materials Science and Engineering, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan, 30013, Republic of China.
² Department of Physics, The University of York, York, YO10 5DD, UK.
³ The Centre for High Resolution Neutron Scattering, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA.
⁴ Engineering and the Environment, University of Southampton, Southampton, SO16 7QF, UK.
⁵ Department of Engineering and System Science, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan, 30013, Republic of China.
⁶ Department of Chemistry, National Chung Hsing University, No. 145 Xingda Rd., South Dist., Taichung City, 402, Taiwan.

PMID: 30311278
DOI: 10.1002/adma.201802444

Abstract

The controlled size and surface treatment of magnetic nanoparticles (NPs) make one-stage combination feasible for enhanced magnetic resonance imaging (MRI) contrast and effective hyperthermia. However, superparamagnetic behavior, essential for avoiding the aggregation of magnetic NPs, substantially limits their performance. Here, a superparamagnetic core-shell structure is developed, which promotes the formation of vortex-like intraparticle magnetization structures in the remanent state, leading to reduced dipolar interactions between two neighboring NPs, while during an MRI scan, the presence of a DC magnetic field induces the formation of NP chains, introducing increased local inhomogeneous dipole fields that enhance relaxivity. The core-shell NPs also reveal an augmented anisotropy, due to exchange coupling to the high anisotropy core, which enhances the specific absorption rate. This in vivo tumor study reveals that the tumor cells can be clearly diagnosed during an MRI scan and the tumor size is substantially reduced through hyperthermia therapy by using the same FePt@iron oxide nanoparticles, realizing the concept of theranostics.

Keywords: core-shell; hyperthermia; magnetic interaction; magnetic resonance image; theranostics.

Abstract

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