Autonomic Disturbances in Acute Cerebrovascular Disease

Neurosci Bull. 2019 Feb;35(1):133-144. doi: 10.1007/s12264-018-0299-2. Epub 2018 Oct 11.

Abstract

Autonomic disturbances often occur in patients with acute cerebrovascular disease due to damage of the central autonomic network. We summarize the structures of the central autonomic network and the clinical tests used to evaluate the functions of the autonomic nervous system. We review the clinical and experimental findings as well as management strategies of post-stroke autonomic disturbances including electrocardiographic changes, cardiac arrhythmias, myocardial damage, thermoregulatory dysfunction, gastrointestinal dysfunction, urinary incontinence, sexual disorders, and hyperglycemia. The occurrence of autonomic disturbances has been associated with poor outcomes in stroke patients. Autonomic nervous system modulation appears to be an emerging therapeutic strategy for stroke management in addition to treatments for sensorimotor dysfunction.

Keywords: Autonomic disturbance; Autonomic nervous system; Cerebrovascular disease; Stroke.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Autonomic Nervous System / physiopathology*
  • Cerebrovascular Disorders / complications
  • Cerebrovascular Disorders / physiopathology*
  • Humans
  • Nerve Net / injuries*
  • Sensorimotor Cortex / physiopathology*
  • Stroke / physiopathology*