The Fountain of Youth: It's All in Our Veins

Amaia Dominguez-Belloso; Stefan Liebner

doi:10.1016/j.neuron.2018.09.038

The Fountain of Youth: It's All in Our Veins

Neuron. 2018 Oct 10;100(1):9-11. doi: 10.1016/j.neuron.2018.09.038.

Authors

Amaia Dominguez-Belloso¹, Stefan Liebner²

Affiliations

¹ Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Heinrich-Hoffmann-Straße 7, 60528 Frankfurt, Germany.
² Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Heinrich-Hoffmann-Straße 7, 60528 Frankfurt, Germany. Electronic address: stefan.liebner@kgu.de.

PMID: 30308174
DOI: 10.1016/j.neuron.2018.09.038

Abstract

Cardiovascular dysfunction becomes recognized as a risk for dementia. In this issue of Neuron, Park et al. (2018) report the age-related, brain endothelial-specific upregulation of acid sphingomyelinase (ASM), leading to blood-brain barrier malfunction, neurodegeneration, and memory deficits that were mitigated by ASM inhibition in mice.

Keywords: acid sphingomyelinase; blood-brain barrier; caveolae; caveolin-1; dementia; permeability.

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MeSH terms

Animals
Blood-Brain Barrier
Caveolin 1*
Mice
Neurogenesis
Rejuvenation
Sphingomyelin Phosphodiesterase*

Substances

Caveolin 1
Sphingomyelin Phosphodiesterase